ABSTRACT
Objectives: Covid-19 was affected all over the world and caused pandemic. Compelling data suggest that Covid-19 might influence all human parts. Host of studies showed that metabolic syndrome (MetS) was associated with nonalcoholic fatty liver disease (NAFLD). Purpose of the study was to evaluate the possible impact of MetS components in the course of Covid-19 in patients with NAFLD. Materials and Methods: 192 consecutive patients (aged 37-75 years;mean age 56.2 ± 13.2 years;male = 48%) with NAFLD and MetS who underwent Covid-19 were enrolled in this study. Patients were divided into two groups by 91 in each group according to the presence or absence of MetS. All anthropometric, laboratory and instrumental data were obtained and analyzed at baseline. All statistical analysis were performed by SPSS 24.0 software. Results: Patients with concomitant MetS (Group I) had severe Covid- 19 than those without it (P<0.05). 19% out of Group I patients had severe Covid-19 whilst 12% out of Group II patients had severe course of the invective disease. Multiple regression logistic analysis showed that among MetS components having abdominal obesity (AO) (2.7;1.6-4.4;CI 95%;P<0.05), insulin resistance (IR) (2.0;1.4-3.9' CI 95%;P<0.05), hypertension (HT) (1.4;1.3-2.4;CI 95%;P<0.05) tended have a severe Covid-19 in patients with NAFLD. When we separately analyzed by gender there was not significant changes between male and female (P[0.05). Conclusion: MetS was significantly associated with severe Covid-19 in patients with NAFLD. Among MetS components AO, IR and HT independently associated with severe Covid-19 regardless of gender. Further investigations are required with large amount of participants.